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ea0037gp.16.03 | Diabetes and obesity–Clinical obesity and cardiovascular | ECE2015

The dipeptidyl peptidase-IV inhibitor (gemigliptin) inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanisms

Hong Ho Cheol , Hwang Hwan-Jin , Lee Hyun Jung , Lee Min Jung , Seo Ji A , Kim Sin Gon , Kim Nan Hee , Choi Kyung Mook , Choi Dong Seop , Baik Sei Hyun , Yoo Hye Jin

Recently, dipeptidyl peptidase-IV (DPP-IV) inhibitor, a major anti-hyperglycaemic agent, has received substantial attention as a possible therapeutic target for inflammatory diseases such as atherosclerosis. However, the direct molecular mechanisms through which DPP-IV inhibitor mediates anti-inflammatory effects in vascular endothelial cells have not been clarified. The effects of the DPP-IV inhibitor, gemigliptin, were analysed in human umbilical vein endothelial cells (HUVE...

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The dipeptidyl peptidase-IV inhibitor (gemigliptin) inhibits the expression of vascular adhesion molecules and inflammatory cytokines in HUVECs via Akt- and AMPK-dependent mechanisms

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